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apalutamide will reduce the extent or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medication which have been CYP3A4 substrates may result in decreased exposure to those drugs.Antihistamines: concomitant administrat